Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.

@article{Petitjean2007ImpactOM,
  title={Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.},
  author={Audrey Petitjean and Ewy Mathe and Shunsuke Kato and Chikashi Ishioka and Sean V. Tavtigian and Pierre Hainaut and Magali Olivier},
  journal={Human mutation},
  year={2007},
  volume={28 6},
  pages={622-9}
}
The tumor suppressor gene TP53 is frequently mutated in human cancers. More than 75% of all mutations are missense substitutions that have been extensively analyzed in various yeast and human cell assays. The International Agency for Research on Cancer (IARC) TP53 database (www-p53.iarc.fr) compiles all genetic variations that have been reported in TP53. Here, we present recent database developments that include new annotations on the functional properties of mutant proteins, and we perform a… CONTINUE READING
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