Impact of modified ribose sugars on nucleic acid conformation and function

  title={Impact of modified ribose sugars on nucleic acid conformation and function},
  author={Marina Evich and Alexander M. Spring-Connell and M. Germann},
  journal={Heterocyclic Communications},
  pages={155 - 165}
  • Marina Evich, Alexander M. Spring-Connell, M. Germann
  • Published 2017
  • Chemistry
  • Heterocyclic Communications
  • Abstract The modification of the ribofuranose in nucleic acids is a widespread method of manipulating the activity of nucleic acids. These alterations, however, impact the local conformation and chemical reactivity of the sugar. Changes in the conformation and dynamics of the sugar moiety alter the local and potentially global structure and plasticity of nucleic acids, which in turn contributes to recognition, binding of ligands and enzymatic activity of proteins. This review article introduces… CONTINUE READING
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