Impact of modafinil on prefrontal executive function in schizophrenia.

  title={Impact of modafinil on prefrontal executive function in schizophrenia.},
  author={Michael D. Hunter and Venkatasubramanian Ganesan and Iain D. Wilkinson and Sean A. Spence},
  journal={The American journal of psychiatry},
  volume={163 12},
OBJECTIVE The purpose of this study was to investigate the acute effects of modafinil on prefrontal activation and cognitive control of motor activity in people with schizophrenia and prominent negative symptoms. METHOD In a crossover design, 12 subjects with schizophrenia were studied twice, receiving either modafinil or placebo prior to functional magnetic resonance imaging (fMRI). Inside the scanner, they performed a task probing cognitive control that required deliberate variation of… CONTINUE READING

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