Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomised, placebo controlled trial.

@article{McDonald1997ImpactOM,
  title={Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomised, placebo controlled trial.},
  author={Helen M McDonald and Jill A O'Loughlin and Rasiah Vigneswaran and Phyllis Jolley and Jennifer A. Harvey and A Bof and Peter J. McDonald},
  journal={British journal of obstetrics and gynaecology},
  year={1997},
  volume={104 12},
  pages={1391-7}
}
OBJECTIVE To ascertain whether metronidazole treatment of women with a heavy growth of Gardnerella vaginalis during mid-pregnancy would reduce the risk of spontaneous preterm birth. DESIGN A multicentre, randomised, placebo-controlled trial. SETTING Four metropolitan hospitals. PARTICIPANTS Eight hundred and seventy-nine singleton women with a heavy growth of G. vaginalis or Gram stain indicative of bacterial vaginosis at 19 weeks of gestation. INTERVENTIONS Oral metronidazole (400 mg… CONTINUE READING

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