Impact of methylation of acyl glucuronide metabolites on incurred sample reanalysis evaluation: ramiprilat case study.

@article{Ct2011ImpactOM,
  title={Impact of methylation of acyl glucuronide metabolites on incurred sample reanalysis evaluation: ramiprilat case study.},
  author={Cynthia C{\^o}t{\'e} and Mathieu Lahaie and Sylvain Latour and M{\'e}lanie Bergeron and Catherine Dicaire and Natasha Savoie and Milton Furtado and Fabio Garofolo},
  journal={Bioanalysis},
  year={2011},
  volume={3 9},
  pages={951-65}
}
BACKGROUND Reanalysis of incurred samples showed that the bioanalytical method for the quantification of ramipril and ramiprilat was generating irreproducible results for ramiprilat. RESULTS An additional peak interfering with ramiprilat was observed in the incurred samples but not in the calibrant and quality control samples. A similar interference was… CONTINUE READING