Impact of meningeal dissemination (MD) on outcome in primary CNS lymphoma in the G-PCNSL-SG1 trial.

@article{Korfel2011ImpactOM,
  title={Impact of meningeal dissemination (MD) on outcome in primary CNS lymphoma in the G-PCNSL-SG1 trial.},
  author={Agnieszka Korfel and Lars Fischer and Peter Martus and Robert Moehle and H. A. Klasen and Michael Rauch and Alexander Roeth and Bernd Hertenstein and Thomas J. Fischer and H G Mergenthaler and Thomas Hundsberger and Malte Leith{\"a}user and Tobias Birnbaum and Axel Florsch{\"u}tz and Kristoph Jahnke and Ulrich Herrlinger and Michael Weller and Eckhard Thiel},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 15\_suppl},
  pages={2026}
}
  • A. Korfel, L. Fischer, +15 authors E. Thiel
  • Published 2011
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2026 Background: The prognostic impact of MD in PCNSL is still debated. Within the framework of a multicenter randomized trial (G-PCNSL-SG1) we evaluated patients for outcome according to the presence of MD. METHODS Immunocompetent adult patients were initially treated with up to six cycles of high-dose methotrexate (HD-MTX; 4g/m2) based chemotherapy without intrathecal therapy. Those randomized to radiotherapy subsequently received whole-brain radiotherapy (WBRT) with 45 Gy, in 1.5 Gy… Expand
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