Impact of manganese on primary hippocampal neurons from rodents.

  title={Impact of manganese on primary hippocampal neurons from rodents.},
  author={Alexia Daoust and Yasmina Saoudi and Jacques Brocard and Nora Collomb and C{\'e}cile Batandier and Mariano Bisbal and Murielle Salom{\'e} and Annie Andrieux and Sylvain Bohic and Emmanuel Luc Barbier},
  volume={24 5},
Manganese-enhanced magnetic resonance imaging (MEMRI) is a powerful tool for in vivo tract tracing or functional imaging of the central nervous system. However Mn(2+) may be toxic at high levels. In this study, we addressed the impact of Mn(2+) on mouse hippocampal neurons (HN) and neuron-like N2a cells in culture, using several approaches. Both HN and N2a cells not exposed to exogenous MnCl2 were shown by synchrotron X-ray fluorescence to contain 5 mg/g Mn. Concentrations of Mn(2+) leading to… CONTINUE READING