Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels.

@article{Agledahl2009ImpactOL,
  title={Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels.},
  author={Ingvild Agledahl and Ellen E. Brodin and Johan Svartberg and John-Bjarne Hansen},
  journal={Thrombosis and haemostasis},
  year={2009},
  volume={102 5},
  pages={945-50}
}
Men have a higher incidence of cardiovascular disease (CVD) than women of similar age, and it has been suggested that testosterone may influence the development of CVD. Recently, we demonstrated that elderly men with low testosterone levels had lower plasma levels of free tissue factor pathway inhibitor (TFPI) Ag associated with shortened tissue factor (TF)-induced coagulation initiation in a population based case-control study. Our hypothesis was that one year of testosterone treatment to… CONTINUE READING