Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis.

  title={Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis.},
  author={Toshihito Kosaka and Junji Yoshino and Kazuo Inui and Takao Wakabayashi and Kazumu Okushima and Takashi Kobayashi and Hironao Miyoshi and Yuta Nakamura and Shigekazu Hayashi and Taizou Shiraishi and Masatoshi Watanabe and Takayuki Yamamoto and Ai Nakahara and Takahiko Katoh},
  journal={World journal of gastroenterology},
  volume={12 39},
AIM To examine the influence of lipoprotein lipase (LPL) gene polymorphism in ulcerative colitis (UC) patients. METHODS Peripheral blood was obtained from 131 patients with UC and 106 healthy controls for DNA extraction. We determined LPL gene polymorphisms affecting the enzyme at Ser447stop, as well as Hind III and Pvu II polymorphisms using PCR techniques. PCR products were characterized by PCR-RFLP and direct sequencing. Polymorphisms were examined for association with clinical features in… CONTINUE READING