Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures

@article{Sorrentino2010ImpactOL,
  title={Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures},
  author={Flavia Sorrentino and Ipsita Roy and Tajalli Keshavarz},
  journal={Applied Microbiology and Biotechnology},
  year={2010},
  volume={88},
  pages={65-73}
}
This work proposes a novel approach for enhancing the yield of lovastatin in Aspergillus terreus cultures by exploiting linoleic acid-derived signalling molecules, which are potentially involved in fungal cell–cell communication. High-performance liquid chromatography analysis revealed that production of lovastatin was enhanced up to 1.8-fold upon exogenous addition of the oxylipin precursor linoleic acid to low cell density cultures of A. terreus. Real-time PCR analysis showed that… CONTINUE READING

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