Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia.

Abstract

Apoptotic hepatocytes have been demonstrated to represent an important signal for transmigration of leukocytes sequestered in sinusoids during endotoxemia in vivo. Beside leukocytes, platelets and their adhesion to endothelial cells and leukocytes have been implicated in inflammatory liver injury. Using in vivo multifluorescence microscopy, we examined the… (More)

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