Changing from a co-education to a singlegender learning environment could be an opportunity and a challenge to any institute. Software engineering is one of the fields that could be affected by gendersegregation policies. Teaching the subject involves group and individual activities which could be dramatically affected in single-gender settings. In this paper, we present our experience in teaching software engineering in gender segregated classes. We will compare the performance of students before and after gender segregation. We will show samples of the activities and the findings. We will have a discussion about the impact of gender segregation on the overall course performance. Our findings could be useful in providing strategies to enhance the higher education learning experience and to eliminate future gender divide issues in the workplace.