• DOI:10.1200/JCO.2011.38.4818
• Corpus ID: 21128105

Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis.

@article{deWittHamer2012ImpactOI,
  title={Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis.},
  author={Philip C. de Witt Hamer and Santiago Gil Robles and Aeilko H. Zwinderman and Hugues Duffau and Mitchel S. Berger},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2012},
  volume={30 20},
  pages={
          2559-65
        }
}

• P. C. de Witt Hamer, S. G. Robles, +2 authors M. Berger
• Published 10 July 2012
• Medicine
• Journal of clinical oncology : official journal of the American Society of Clinical Oncology

PURPOSE
Surgery for infiltrative gliomas aims to balance tumor removal with preservation of functional integrity. The usefulness of intraoperative stimulation mapping (ISM) has not been addressed in randomized trials. This study addresses glioma surgery outcome on the basis of a meta-analysis of observational studies.

METHODS
A systematic search retrieved 90 reports published between 1990 and 2010 with 8,091 adult patients who had resective surgery for supratentorial infiltrative glioma, with or without ISM. Quality criteria consisted of postoperative neurologic examination details and follow-up timing. New postoperative neurologic deficits were categorized on the basis of timing and severity. Meta-analysis with a Bayesian random effects model determined summary event rates of deficits as well as gross total resection rate and eloquent locations. Meta-regression analysis explored heterogeneity among studies.

RESULTS
Late severe neurologic deficits were observed in 3.4% (95% CI, 2.3% to 4.8%) of patients after resections with ISM, and in 8.2% (95% CI, 5.7% to 11.4%) of patients after resections without ISM (adjusted odds ratio, 0.39; 95% CI, 0.23 to 0.64). The percentages of radiologically confirmed gross total resections were 75% (95% CI, 66% to 82%) with ISM and 58% (95% CI, 48% to 69%) without ISM. Eloquent locations were involved in 99.9% (95% CI, 99.9% to 100%) of resections with ISM and in 95.8% (95% CI, 73.1% to 99.8%) of resections without ISM. Relevant sources of heterogeneity among studies were ISM, continent, and academic setting.

CONCLUSION
Glioma resections using ISM are associated with fewer late severe neurologic deficits and more extensive resection, and they involve eloquent locations more frequently. This indicates that ISM should be universally implemented as standard of care for glioma surgery.