Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice

@article{Savale2009ImpactOI,
  title={Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice},
  author={Laurent Savale and Ly Tu and Dominique Rideau and Mohamed Izziki and Bernard Ma{\^i}tre and Serge Adnot and Saadia Eddahibi},
  journal={Respiratory Research},
  year={2009},
  volume={10},
  pages={6 - 6}
}
BackgroundInflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for interleukin-6 (IL-6).MethodsTo determine whether endogenous IL-6 contributes to mediate hypoxic PH and lung inflammation, we studied IL-6-deficient (IL-6-/-) and wild-type (IL-6+/+) mice exposed to hypoxia for 2 weeks.ResultsRight ventricular systolic pressure, right ventricle… CONTINUE READING

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