Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C.

@article{Ralln2011ImpactOI,
  title={Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C.},
  author={Norma Rall{\'o}n and J Antonio Morello and Pablo Labarga and Jos{\'e} Miguel Benito and Sonia Rodr{\'i}guez-N{\'o}voa and Eugenia Vispo and Pablo Barreiro and Mar{\'i}a {\'A}ngeles Castro and Koldo Aguirrebengoa and Juan Pineda and Pilar Miralles and Mar{\'i}a Jes{\'u}s T{\'e}llez and Joaqu{\'i}n Portu and Celia Miralles and Antonio Ocampo and Vicente Soriano},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2011},
  volume={53 12},
  pages={1291-5}
}
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection. Anemia developed in 80% of patients with normal ITPA activity compared with 33% of those with reduced ITPA activity. In contrast, ITPA variants did not… CONTINUE READING