Impact of injection speed and volume on perceived pain during subcutaneous injections into the abdomen and thigh: a single‐centre, randomized controlled trial

@article{Heise2014ImpactOI,
  title={Impact of injection speed and volume on perceived pain during subcutaneous injections into the abdomen and thigh: a single‐centre, randomized controlled trial},
  author={Tim Heise and Leszek Nosek and Sibylle Dellweg and Eric Zijlstra and Kezia Ann Pr{\ae}stmark and Jonas Kildegaard and G Nielsen and Thomas Sparre},
  journal={Diabetes},
  year={2014},
  volume={16}
}
The aim of this study was to assess pain associated with subcutaneous injection into the abdomen and thigh of different combinations of injection speeds and volumes. 
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63 Citations
Highly Influential Citations
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Background Citations
20
Methods Citations
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Results Citations
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Impact of Injection Speed, Volume, and Site on Pain Sensation
TLDR
Large volume and thigh injections are rated more painful, but the clinical impact of these findings is likely marginal considering the low absolute pain levels and high patient acceptance rates.
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Adherence to subcutaneous anti‐TNFα agents in patients with rheumatoid arthritis is largely influenced by pain and skin sensations at the injection site
The aims of this prospective study were to determine the dimension of adherence in rheumatoid arthritis (RA) patients receiving subcutaneously administered anti‐tumor necrosis factor‐α (anti‐TNFα)…
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TLDR
The large volume injections tested, 1–20 cP viscosities up to 10ml in the abdomen and 5 ml in the thigh, are feasible with good subject acceptability and rapid resolution of tissue effects and pain.
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TLDR
The PRECISE II human study demonstrated that the PRIME needle-free injection system was safe, well tolerated, and strongly preferred by participants for self-injections over a standard needle and syringe.
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It is shown that a 1.0-mL saline injection can be given with less pain reported than a standard subcutaneous injection using a 27G needle, and this new needle-free delivery system may lead to improved satisfaction and compliance, as well as reduced anxiety among patients requiring frequent or ongoing injections.
Pen needle design influences ease of insertion, pain, and skin trauma in subjects with type 2 diabetes
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The shape and design of a needle and the needle tip affect ease of insertion, pain and skin trauma, and Relations are seen across different data acquisition methods and across species, enabling needle performance testing outside of clinical trials.
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References

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