Impact of inhaled nitric oxide on white matter damage in growth-restricted neonatal rats

  title={Impact of inhaled nitric oxide on white matter damage in growth-restricted neonatal rats},
  author={Hoa Pham and An Phan Duy and Julien Pansiot and Bieke Bollen and Jorge Gallego and Christiane Charriaut-Marlangue and Olivier Baud},
  journal={Pediatric Research},
Background:Fetal growth restriction is the second leading cause of perinatal morbidity and mortality, and neonates with intrauterine growth retardation (IUGR) have increased neurocognitive and neuropsychiatric morbidity. These neurocognitive impairments are mainly related to injury of the developing brain associated with IUGR. Growing evidence from preclinical models of brain injury in both adult and neonatal rodents supports the view that nitric oxide can promote neuroprotection.Methods:In a… CONTINUE READING
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