Impact of infections and normal flora in nonhuman primates on drug development.

@article{Sasseville2008ImpactOI,
  title={Impact of infections and normal flora in nonhuman primates on drug development.},
  author={Vito G. Sasseville and Richard W. Diters},
  journal={ILAR journal},
  year={2008},
  volume={49 2},
  pages={179-90}
}
Preclinical safety studies that are required for the marketing approval of a pharmaceutical include single and repeat dose studies in rodent and nonrodent species. The use of nonhuman primates (NHPs), primarily macaques, as the nonrodent species has increased in recent years, in part due to the increase in development of biopharmaceuticals and immunomodulatory agents. Depending on the source of the macaques, they may vary in genetic background, normal flora, and/or the incidence of preexisting… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques.

Regulatory toxicology and pharmacology : RTP • 2015
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…