Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants

@inproceedings{Loughran2014ImpactOI,
  title={Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants},
  author={Allister J. Loughran and Danielle N Atwood and Allison C Anthony and Nada S. Harik and Horace J. Spencer and Karen E. Beenken and Mark S Smeltzer},
  booktitle={MicrobiologyOpen},
  year={2014}
}
We demonstrate that the purified Staphylococcus aureus extracellular proteases aureolysin, ScpA, SspA, and SspB limit biofilm formation, with aureolysin having the greatest impact. Using protease-deficient derivatives of LAC, we confirmed that this is due to the individual proteases themselves. Purified aureolysin, and to a lesser extent ScpA and SspB, also promoted dispersal of an established biofilm. Mutation of the genes encoding these proteases also only partially restored biofilm formation… CONTINUE READING

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