Impact of impaired renal function on the pharmacokinetics of the antiepileptic drug lacosamide.

@article{Cawello2013ImpactOI,
  title={Impact of impaired renal function on the pharmacokinetics of the antiepileptic drug lacosamide.},
  author={Willi Cawello and Uwe Fuhr and Ursula Hering and Haidar Maatouk and Atef Halabi},
  journal={Clinical pharmacokinetics},
  year={2013},
  volume={52 10},
  pages={897-906}
}
BACKGROUND AND OBJECTIVE The antiepileptic drug lacosamide is eliminated predominantly via the kidneys. Therefore, an evaluation of the impact of renal impairment on its pharmacokinetic profile is an important component of its safety assessment. The objective of this study was to evaluate the pharmacokinetic profile of lacosamide among individuals with renal impairment (mild, moderate, or severe) and among patients with end-stage renal disease (ESRD), including those on hemodialysis. METHODS… CONTINUE READING