Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer

@article{Sako2006ImpactOI,
  title={Impact of immunohistochemically identified lymphatic invasion on nodal metastasis in early gastric cancer},
  author={Akihiro Sako and Joji Kitayama and Makoto Ishikawa and Hiroharu Yamashita and Hirokazu Nagawa},
  journal={Gastric Cancer},
  year={2006},
  volume={9},
  pages={295-302}
}
Among various clinical and pathological findings, lymphatic invasion (Ly) is the strongest risk factor for nodal metastasis in gastric cancer. However, the diagnosis of Ly is subjective and often inaccurate because of the difficulty of detecting lymphatic vessels with conventional hematoxylin and eosin (HE) staining. The distribution of lymphatics in the normal gastric wall was immunohistochemically characterized using a new selective marker of lymphatic endothelium, D2-40, in surgical… CONTINUE READING