Impact of hypoxia and long-term cultivation on the genomic stability and mitochondrial performance of ex vivo expanded human stem/stromal cells.

@article{Oliveira2012ImpactOH,
  title={Impact of hypoxia and long-term cultivation on the genomic stability and mitochondrial performance of ex vivo expanded human stem/stromal cells.},
  author={Pedro H Oliveira and Joana S. Boura and Manuel M A Abecasis and Jeffrey M. Gimble and Cl{\'a}udia L da Silva and Joaquim M S Cabral},
  journal={Stem cell research},
  year={2012},
  volume={9 3},
  pages={225-36}
}
Recent studies have described the occurrence of chromosomal abnormalities and mitochondrial dysfunction in human stem/stromal cells (SCs), particularly after extensive passaging in vitro and/or expansion under low oxygen tensions. To deepen this knowledge we investigated the influence of hypoxia (2% O(2)) and prolonged passaging (>P10) of human bone marrow stromal cells (BMSCs) and adipose-derived stromal cells (ASCs) on the expression of genes involved in DNA repair and cell-cycle regulation… CONTINUE READING
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