Impact of hypertonic saline on hospitalization rate in infants with acute bronchiolitis: A meta‐analysis

  title={Impact of hypertonic saline on hospitalization rate in infants with acute bronchiolitis: A meta‐analysis},
  author={Linjie Zhang and Carlos B Gunther and Ozeias Sim{\~o}es Franco and Terry P Klassen},
  journal={Pediatric Pulmonology},
  pages={1089 - 1095}
This meta‐analysis aimed to assess the efficacy of nebulized hypertonic saline (HS) on the rate of hospitalization in infants with acute bronchiolitis in the Emergency Department (ED) setting. 
Exploring the appropriate dose of nebulized hypertonic saline for bronchiolitis: a dose–response meta-analysis
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This study showed that nebulized HS is an effective and safe therapy for bronchiolitis and found that there was no significant difference between 3% HS and the higher doses (>3%) of HS in LOS and 24-hour CSS. Expand
The cost-effectiveness of hypertonic saline inhalations for infant bronchiolitis
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  • Expert review of respiratory medicine
  • 2019
This review focuses on the role of racemic epinephrine, systemic corticosteroids, hypertonic saline and high-flow oxygen therapy (HFOT) in the treatment of infants with bronchiolitis. Expand
Budget Impact Analysis of Hypertonic Saline Inhalations for Infant Bronchiolitis: The Colombian National Health System Perspective.
HS was cost saving in emergency settings for treating infants with acute bronchiolitis in Colombia and can be used by decision makers in Colombia to improve clinical practice guidelines and should be replicated to validate their results in other middle-income countries. Expand
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Nebulized hypertonic saline 3% for 1 versus 3 days in hospitalized bronchiolitis: a blinded non-inferiority randomized controlled trial
Results seem not to be in favour of reducing the duration of nebulised HS treatment from 3 to 1 day in acute moderate bronchiolitis, with a non-significant tendency for less need of nutritional support and supplemental oxygen in HS3d group. Expand
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Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial
Nebulized HS treatment did not significantly reduce the rate of hospital admissions among infants with a first episode of acute moderate to severe bronchiolitis who were admitted to the pediatric ED relative to NS, but mild adverse events were more frequent in the HS group. Expand
Hypertonic Saline in Acute Bronchiolitis : A Randomized Controlled Trial
  • 2013
BACKGROUND: Research suggests that hypertonic saline (HS) may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improvedExpand
7% Hypertonic Saline in Acute Bronchiolitis: A Randomized Controlled Trial
In moderate to severe acute bronchiolitis, inhalation of 7% HS with epinephrine does not appear to confer any clinically significant decrease in BSS when compared with 0.9% saline with epinphrine. Expand
Nebulized hypertonic saline for bronchiolitis in the emergency department: a randomized clinical trial.
Infants with bronchiolitis and persistent respiratory distress after standard treatment in the emergency department had less improvement after receiving 3% HS compared with those who received NS, and administration of a single dose of3% HS does not appear to be indicated to treat bronchiolaitis in the acute care setting. Expand
Effect of inhaled hypertonic saline on hospital admission rate in children with viral bronchiolitis: a randomized trial.
The short-term use of nebulized 3% HS did not result in any statistically significant benefits, although a nonsignificant trend toward a decrease in admission rate and improvement in respiratory distress was found. Expand
SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis
This study does not support the use of nebulised HS in the treatment of acute bronchiolitis over usual care with minimal handlings and no difference in adverse events. Expand
Nebulized Hypertonic Saline for Acute Bronchiolitis: A Systematic Review
Nebulized HS is a safe and potentially effective treatment of infants with acute bronchiolitis and the quality of evidence is moderate due to inconsistency in results between trials and study limitations. Expand
Maybe there is no such thing as bronchiolitis
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  • Medicine
  • Canadian Medical Association Journal
  • 2016
Physicians who have been in practice for 30 years or more have ridden the rollercoaster of optimism following the publication of randomized controlled trials aboutiral bronchiolitis. Expand
Hypertonic saline inhalations in bronchiolitis—A cumulative meta‐analysis
In conclusion, HS inhalations offered only limited clinical benefits, though the differences between HS and control groups were statistically significant, and the heterogeneity between the studies was substantial. Expand
Nebulized hypertonic saline for bronchiolitis: a randomized clinical trial.
Hypertonic saline given to children with bronchiolitis in the ED decreases hospital admissions and can detect no significant difference in Respiratory Distress Assessment Instrument score or length of stay between the HS and NS groups. Expand