Impact of hyperglycemia on early embryo development and embryopathy: in vitro experiments using a mouse model.


BACKGROUND The aim of this study is to model the processes of early embryopathy seen in human pregnancy complicated by maternal hyperglycemia secondary to maternal diabetes using a mouse embryo culture system. METHODS Female mice were superovulated and mated in pairs. Two-cell embryos were harvested from the oviducts and cultured in vitro in KSOM medium… (More)
DOI: 10.1093/humrep/den333


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