Impact of highly conserved HLA haplotype on acute graft-versus-host disease.

  title={Impact of highly conserved HLA haplotype on acute graft-versus-host disease.},
  author={Satoko Morishima and Seishi Ogawa and Aiko Matsubara and Takakazu Kawase and Yasuhito Nannya and Koichi Kashiwase and Masahiro Satake and Hiroo Saji and Hidetoshi Inoko and Shunichi Kato and Yoshihisa Kodera and Takehiko Sasazuki and Yasuo Morishima},
  volume={115 23},
Although the effects of human leukocyte antigen (HLA) locus matching on clinical outcome in unrelated hematopoietic stem cell transplantations have been characterized, the biologic implications of HLA haplotypes have not been defined. We demonstrated the genetic fixity of Japanese conserved extended haplotypes by multi-single nucleotide polymorphism analysis in 1810 Japanese donor-recipient pairs matching with HLA-A, -B, -C, -DRB1, and -DQB1 alleles. Three major Japanese conserved extended… CONTINUE READING
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