Impact of high-throughput screening in biomedical research

@article{Macarrn2011ImpactOH,
  title={Impact of high-throughput screening in biomedical research},
  author={Ricardo Macarr{\'o}n and Martyn N. Banks and Dejan Bojanic and David J. Burns and Dragan A. Cirovic and Tina Garyantes and Darren V. S. Green and Robert P. Hertzberg and William P. Janzen and Jeff W. Paslay and Ulrich Schopfer and G. Sitta Sittampalam},
  journal={Nature Reviews Drug Discovery},
  year={2011},
  volume={10},
  pages={188-195}
}
High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes. 
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Historically, drug discovery relied on phenotypic drug discovery (PDD), also known as “classical pharmacology”, which represented a practical approach where compounds were screened on intact cells or
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TLDR
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TLDR
Methods employed in the AstraZeneca HTS laboratory to carry out very large scale cell toxicity screening are described, which demonstrates the ability to measure toxicity of compounds on a large scale.
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