Impact of heterodimerization on intracellular localization of the ecdysteroid receptor (EcR).

@article{Nieva2008ImpactOH,
  title={Impact of heterodimerization on intracellular localization of the ecdysteroid receptor (EcR).},
  author={Claudia Nieva and Margarethe Spindler-Barth and K. Spindler},
  journal={Archives of insect biochemistry and physiology},
  year={2008},
  volume={68 1},
  pages={
          40-8
        }
}
  • Claudia Nieva, Margarethe Spindler-Barth, K. Spindler
  • Published in
    Archives of insect…
    2008
  • Medicine, Biology
  • Initially, nuclear import of the ecdysteroid receptor (EcR) in vertebrate cells (CHO-K1 and COS-7) does not afford a heterodimerization partner. Later on, EcR is retained in the nucleus only in the presence of a heterodimerization partner. Ultraspiracle (Usp) is more efficient compared to its vertebrate orthologue RXR and leads to an exclusively nuclear localization of EcR even in the absence of ligand. The DNA binding domain of the heterodimerization partner is important for retainment of EcR… CONTINUE READING

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