Impact of hepatitis C virus heterogeneity on interferon sensitivity: an overview.

@article{ElShamy2014ImpactOH,
  title={Impact of hepatitis C virus heterogeneity on interferon sensitivity: an overview.},
  author={Ahmed El-Shamy and Hak Hotta},
  journal={World journal of gastroenterology},
  year={2014},
  volume={20 24},
  pages={
          7555-69
        }
}
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. HCV is able to evade host defense mechanisms, including both innate and acquired immune responses, to establish persistent infection, which results in a broad spectrum of pathogenicity, such as lipid and glucose metabolism disorders and hepatocellular carcinoma development. The HCV genome is characterized by a high degree of genetic diversity, which can be associated with viral sensitivity or resistance (reflected by different… CONTINUE READING

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