Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection.

@article{Lee2011ImpactOH,
  title={Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection.},
  author={Jong-Han Lee and Kwang-hyub Han and Jae Myun Lee and Jeon Han Park and Hyon Suk Kim},
  journal={Clinical and vaccine immunology : CVI},
  year={2011},
  volume={18 6},
  pages={914-21}
}
The hepatitis B virus (HBV) PreS mutations C1653T, T1753V, and A1762T/G1764A were reported as a strong risk factor of hepatocellular carcinoma (HCC) in a meta-analysis. HBV core promoter overlaps partially with HBx coding sequence, so the nucleotide 1762 and 1764 mutations induce HBV X protein (HBx) 130 and 131 substitutions. We sought to elucidate the impact of HBx mutations on HCC development. Chronically HBV-infected patients were enrolled in this study: 42 chronic hepatitis B (CHB) patients… CONTINUE READING
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