Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.

@article{Lipshultz2013ImpactOH,
  title={Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.},
  author={Steven E. Lipshultz and Stuart R. Lipsitz and Jeffery L. Kutok and Tracie L. Miller and Steven D. Colan and Donna S Neuberg and Kristen E. Stevenson and Mark D Fleming and Stephen E. Sallan and Vivian I. Franco and Jacqueline M. Henkel and Barbara L. Asselin and Uma H Athale and Luis A Clavell and Bruno Michon and Caroline Laverdi{\`e}re and Eric C. Larsen and Kara M Kelly and Lewis B. Silverman},
  journal={Cancer},
  year={2013},
  volume={119 19},
  pages={3555-62}
}
BACKGROUND Doxorubicin is associated with progressive cardiac dysfunction, possibly through the formation of doxorubicin-iron complexes leading to free-radical injury. The authors determined the frequency of hemochromatosis (HFE) gene mutations associated with hereditary hemochromatosis and their relationship with doxorubicin-associated cardiotoxicity in survivors of childhood high-risk acute lymphoblastic leukemia. METHODS Peripheral blood was tested for 2 common HFE allelic variants: C282Y… CONTINUE READING
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