Impact of heme oxygenase‐1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia

@article{Hascalovici2009ImpactOH,
  title={Impact of heme oxygenase‐1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia},
  author={Jacob R. Hascalovici and Wei Song and Jacob Vaya and Soliman Khatib and Bianca Fuhrman and Michael Aviram and Hyman M. Schipper},
  journal={Journal of Neurochemistry},
  year={2009},
  volume={108}
}
Up‐regulation of heme oxygenase‐1 (HO‐1) and altered cholesterol (CH) metabolism are characteristic of Alzheimer‐diseased neural tissues. The liver X receptor (LXR) is a molecular sensor of CH homeostasis. In the current study, we determined the effects of HO‐1 over‐expression and its byproducts iron (Fe2+), carbon monoxide (CO) and bilirubin on CH biosynthesis, CH efflux and oxysterol formation in cultured astroglia. HO‐1/LXR interactions were also investigated in the context of CH efflux. hHO… 

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