Impact of haloperidol and risperidone on gene expression profile in the rat cortex.

  title={Impact of haloperidol and risperidone on gene expression profile in the rat cortex.},
  author={Lili{\'a}na Z. Feh{\'e}r and J{\'a}nos K{\'a}lm{\'a}n and L{\'a}szl{\'o} G. Pusk{\'a}s and G{\'a}bor Gy{\"u}lv{\'e}szi and Kl{\'a}ra Kitajka and Botond Penke and Mikl{\'o}s Palot{\'a}s and Elena I Samarova and J{\'o}zsef Moln{\'a}r and {\'A}gnes Zvara and Keyvan Matin and Nikoletta B{\'o}di and Marietta Hugyecz and Magdolna P{\'a}k{\'a}ski and Annam{\'a}ria Bjelik and A. G{\'e}mesn{\'e} Juh{\'a}sz and G{\'a}bor Bog{\'a}ts and Zolt{\'a}n Janka and Andr{\'a}s Palot{\'a}s},
  journal={Neurochemistry international},
  volume={47 4},
Despite the clinical efficacy of the most thoroughly studied conventional neuroleptic agent haloperidol, and the atypical antipsychotic risperidone is well established, little information is available on their molecular effects. Recent advances in high-density DNA microarray techniques allow the possibility to analyze thousands of genes simultaneously for their differential gene expression patterns in various biological processes, and to determine mechanisms of drug action. The aim of this… CONTINUE READING

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