Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation.

Abstract

We retrospectively examined the association of polymorphisms in the CYP3A, CYP2J2, CYP2C8, and ABCB1 genes with pharmacokinetic (PKs) and pharmacodynamic (PDs) parameters of tacrolimus in 103 renal transplant recipients for a period of 1 year. CYP3A5 expressers had lower predose concentrations (C(0) )/dose and higher dose requirements than nonexpressers… (More)
DOI: 10.1111/j.1432-2277.2012.01446.x

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