Impact of genetic and acquired alteration in cytochrome P450 system on pharmacologic and clinical response to clopidogrel.


Dual antiplatelet therapy with aspirin and clopidogrel has been shown to reduce subsequent cardiac events in patients with acute coronary syndrome or coronary artery stenting. Clopidogrel, a thienopyridine, is a prodrug that is transformed in vivo to an active metabolite by the cytochrome P450 (CYP) enzyme system. The genes encoding CYP enzymes are… (More)
DOI: 10.1016/j.pharmthera.2009.10.008


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