Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study

@inproceedings{ChibaFalek2009ImpactOG,
  title={Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study},
  author={Ornit Chiba-Falek and Marshall Nichols and Sunil Suchindran and John R. Guyton and Geoffrey S. Ginsburg and Elizabeth Barrett-Connor and Jeanette McCarthy},
  booktitle={BMC Medical Genetics},
  year={2009}
}
Several studies have noted that genetic variants of SCARB1, a lipoprotein receptor involved in reverse cholesterol transport, are associated with serum lipid levels in a sex-dependent fashion. However, the mechanism underlying this gene by sex interaction has not been explored. We utilized both epidemiological and molecular methods to study how estrogen and gene variants interact to influence SCARB1 expression and lipid levels. Interaction between 35 SCARB1 haplotype-tagged polymorphisms and… CONTINUE READING

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Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study

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