Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.

  title={Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.},
  author={Shabnam Kharazi and Adam J Mead and Anna Mansour and Anne Hultquist and Charlotta B{\"o}iers and Sidinh Luc and Natalija Buza-Vidas and Zhi Jian Ma and Helen Ferry and Debbie Atkinson and Kristian Reckzeh and Kristina Masson and J{\"o}rg Cammenga and Lars R{\"o}nnstrand and Fumio Arai and Toshio Suda and Claus Nerlov and Ewa Sitnicka and Sten Eirik W Jacobsen},
  volume={118 13},
Acquisition of homozygous activating growth factor receptor mutations might accelerate cancer progression through a simple gene-dosage effect. Internal tandem duplications (ITDs) of FLT3 occur in approximately 25% cases of acute myeloid leukemia and induce ligand-independent constitutive signaling. Homozygous FLT3-ITDs confer an adverse prognosis and are frequently detected at relapse. Using a mouse knockin model of Flt3-internal tandem duplication (Flt3-ITD)-induced myeloproliferation, we… CONTINUE READING


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RK Kancha, N von Bubnoff, C Peschel, J. Duyster
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