Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: consequences for FK506 assimilation.

@article{Lemahieu2005ImpactOG,
  title={Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: consequences for FK506 assimilation.},
  author={Wim P D Lemahieu and Bart Dirk Maes and Kristin Verbeke and Yves F Ch Vanrenterghem},
  journal={Kidney international},
  year={2005},
  volume={67 3},
  pages={1152-60}
}
BACKGROUND Cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (PGP) are important determinants of the oral bioavailability and clearance of tacrolimus. Cimetidine and omeprazole are known modulators of several CYPs in vitro. In the present study, the impact of cimetidine and omeprazole on tacrolimus exposure and on CYP3A4/PGP activity in vivo was examined… CONTINUE READING