Impact of fluorination on proteolytic stability of peptides: a case study with α-chymotrypsin and pepsin

@article{Asante2014ImpactOF,
  title={Impact of fluorination on proteolytic stability of peptides: a case study with α-chymotrypsin and pepsin},
  author={Vivian Asante and J{\'e}r{\'e}mie Mortier and Gerhard Wolber and Beate Koksch},
  journal={Amino Acids},
  year={2014},
  volume={46},
  pages={2733-2744}
}
Protease stability is a key consideration in the development of peptide-based drugs. A major approach to increase the bioavailability of pharmacologically active peptides is the incorporation of non-natural amino acids. Due to the unique properties of fluorine, fluorinated organic molecules have proven useful in the development of therapeutically active small molecules as well as in materials and crop science. This study presents data on the ability of fluorinated amino acids to influence… CONTINUE READING
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