Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.

@article{Ritt2010ImpactOF,
  title={Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.},
  author={Daniel A. Ritt and Daniel M Monson and Suzanne I Specht and Deborah K. Morrison},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 3},
  pages={
          806-19
        }
}
The B-Raf kinase is a Ras pathway effector activated by mutation in numerous human cancers and certain developmental disorders. Here we report that normal and oncogenic B-Raf proteins are subject to a regulatory cycle of extracellular signal-regulated kinase (ERK)-dependent feedback phosphorylation, followed by PP2A- and Pin1-dependent dephosphorylation/recycling. We identify four S/TP sites of B-Raf phosphorylated by activated ERK and find that feedback phosphorylation of B-Raf inhibits… CONTINUE READING

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