Impact of family history of diabetes and ethnicity on -cell function in obese, glucose-tolerant individuals.

@article{Rasouli2007ImpactOF,
  title={Impact of family history of diabetes and ethnicity on -cell function in obese, glucose-tolerant individuals.},
  author={Neda Rasouli and Horace J. Spencer and Amir Adel Rashidi and S. C. Elbein},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 12},
  pages={
          4656-63
        }
}
CONTEXT The increased insulin secretion in response to reduced insulin sensitivity (SI) is heritable, but whether the genetic predisposition is restricted to members of high-risk Caucasian families is unknown. Furthermore, the relative importance of insulin resistance and defective beta-cell compensation in the increased prevalence of type 2 diabetes (T2DM) in African-American compared with Caucasian individuals is uncertain. OBJECTIVES We tested whether obese individuals with a family… CONTINUE READING
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