Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors.

@article{Shimada1996ImpactOE,
  title={Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors.},
  author={Yasuhiro Shimada and David J. Hearse and Metin Avkiran},
  journal={The American journal of physiology},
  year={1996},
  volume={270 2 Pt 2},
  pages={H692-700}
}
There is controversy over whether the cardioprotective effects of Na+/H+ exchanger inhibitors are exerted primarily during ischemia or during subsequent reperfusion, possibly because of interstudy differences in experimental conditions. We studied the impact of perfusate buffer composition on the relative degree of protection afforded by Na+/H+ exchanger inhibition during ischemia vs. reperfusion. Isolated rat hearts (n = 8/group) were perfused (37 degrees C, 75 mmHg) with bicarbonate- or N-2… CONTINUE READING
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