Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease.

@article{Tanabe2011ImpactOE,
  title={Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease.},
  author={Naoya Tanabe and Shigeo Muro and Toyohiro Hirai and Tsuyoshi Oguma and Kunihiko Terada and Satoshi Marumo and Daisuke Kinose and Emiko Ogawa and Yuma Hoshino and Michiaki Mishima},
  journal={American journal of respiratory and critical care medicine},
  year={2011},
  volume={183 12},
  pages={1653-9}
}
RATIONALE Low-attenuation areas assessed by computed tomography reflect the extent of pathological emphysema and correlate with airflow limitation and mortality in patients with chronic obstructive pulmonary disease. The cumulative size distribution of low-attenuation area clusters follows a power law characterized by an exponent, D. The values of D reflect the complexity of the terminal airspace geometry and sensitively detect alveolar structural changes. Exacerbations of chronic obstructive… CONTINUE READING