Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene.

@article{Ouagazzal2003ImpactOE,
  title={Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene.},
  author={A M Ouagazzal and J Moreau and Meike Pauly-Evers and François Jenck},
  journal={Behavioural brain research},
  year={2003},
  volume={144 1-2},
  pages={111-7}
}
Nociceptin/orphanin FQ (N/OFQ) is a newly discovered neuropeptide that has been implicated in the neurobiological regulation of the behavioral responses to stress and fear. To investigate the role of this peptide in the expression of stress/anxiety-related behaviors in mice, a gene targeting approach to disrupt N/OFQ in the pre-proN/OFQ gene was used. The impact of environmental housing conditions (single and social housing) was assessed on N/OFQ-knockout male and female mice in different… CONTINUE READING

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