Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity.

@article{Bhattacharya2012ImpactOE,
  title={Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity.},
  author={Poulomi Bhattacharya and Aileen F. Keating},
  journal={Toxicology and applied pharmacology},
  year={2012},
  volume={261 3},
  pages={227-35}
}
The mammalian ovary is a heterogeneous organ and contains oocyte-containing follicles at varying stages of development. The most immature follicular stage, the primordial follicle, comprises the ovarian reserve and is a finite number, defined at the time of birth. Depletion of all follicles within the ovary leads to reproductive senescence, known as menopause. A number of chemical classes can destroy follicles, thus hastening entry into the menopausal state. The ovarian response to chemical… CONTINUE READING
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