Impact of environmental endocrine disrupting chemicals on the development of obesity

@article{Newbold2010ImpactOE,
  title={Impact of environmental endocrine disrupting chemicals on the development of obesity},
  author={Retha R. Newbold},
  journal={Hormones},
  year={2010},
  volume={9},
  pages={206-217}
}
Environmental chemicals with hormone-like activity can disrupt programming of endocrine signaling pathways during development and result in adverse effects, some of which may not be apparent until much later in life. Recent reports link exposure to environmental endocrine disrupting chemicals during development with adverse health consequences, including obesity and diabetes. These particular diseases are quickly becoming significant public health problems and are fast reaching epidemic… 
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References

SHOWING 1-10 OF 91 REFERENCES
Effects of endocrine disruptors on obesity.
TLDR
An animal model of exposure to diethylstilbestrol that has proven useful in studying mechanisms involved in abnormal programming of various oestrogen target tissues during differentiation is described, suggesting new targets of abnormal programming by endocrine disrupting chemicals.
Developmental exposure to endocrine disruptors and the obesity epidemic.
TLDR
An animal model of developmental exposure to diethylstilbestrol (DES), a potent perinatal endocrine disruptor with estrogenic activity, is described to study mechanisms involved in programming an organism for obesity and suggests new targets of abnormal programming by endocrine disrupting chemicals.
Perinatal exposure to environmental estrogens and the development of obesity.
TLDR
Experimental data support the idea that adipocytes and the mechanisms involved in weight homeostasis are novel targets of abnormal programming of environmental estrogens, some of which are found in the authors' foods as naturally occurring substances or inadvertently as contaminants.
Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling.
TLDR
The environmental obesogen hypothesis predicts that inappropriate receptor activation by organotins will lead directly to adipocyte differentiation and a predisposition to obesity and/or will sensitize exposed individuals to Obesity and related metabolic disorders under the influence of the typical high-calorie, high-fat Western diet.
Endocrine disruptors and the obesity epidemic.
  • J. Heindel
  • Medicine
    Toxicological sciences : an official journal of the Society of Toxicology
  • 2003
TLDR
Research on the site and mechanism of endocrinedisrupting chemicals that have the potential to have a significant impact on human health and research on obesity, which is known to seriously impact human health, are brought together.
Environmental toxins: Exposure to bisphenol A advances puberty
TLDR
It is shown that exposing female mouse fetuses to an EEDC at a dose that is within the range typical of the environmental exposure of humans alters the postnatal growth rate and brings on early puberty in these mice.
New modes of action for endocrine-disrupting chemicals.
TLDR
New avenues through which xenobiotic chemicals influence these and other hormone-dependent signaling pathways are discussed, including those that act on the estrogen, androgen, and thyroid hormone receptors.
Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations.
TLDR
The data point out the unique sensitivity of the developing organism to endocrine-disrupting chemicals, the occurrence of long-term effects after developmental exposure, and the possibility for adverse effects to be transmitted to subsequent generations.
Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens.
  • R. Newbold
  • Biology, Medicine
    Environmental health perspectives
  • 1995
TLDR
Although DES has potent estrogenic activity, it may be used as a model compound to study the effects of weaker environmental estrogens, many of which may fit into the category of endocrine disruptors.
Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome
TLDR
Recent findings on the ability of BPA, at environmentally relevant doses, to inhibit adiponectin and stimulate the release of inflammatory adipokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) from human adipose tissue are summarized.
...
1
2
3
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5
...