Impact of enhancements in the local effect model (LEM) on the predicted RBE-weighted target dose distribution in carbon ion therapy.

@article{Grn2012ImpactOE,
  title={Impact of enhancements in the local effect model (LEM) on the predicted RBE-weighted target dose distribution in carbon ion therapy.},
  author={Rebecca Gr{\"u}n and Thomas Friedrich and Thilo Els{\"a}sser and Michael Kr{\"a}mer and Klemens Zink and Christian P. Karger and Marco Durante and R. Engenhart-Cabillic and Michael Scholz},
  journal={Physics in medicine and biology},
  year={2012},
  volume={57 22},
  pages={7261-74}
}
Biological optimization for treatment planning in carbon ion therapy is currently based on the first version of the local effect model (LEM I). Further developments implemented in the latest version (LEM IV) allowed to predict more accurately the Relative Biological Effectiveness (RBE) in-vitro. The main goal of this study is to compare the LEM IV against LEM I under treatment-like conditions for idealized target geometries. Therefore, physical dose distributions resulting from the biological… CONTINUE READING