Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function.

@article{Chow2007ImpactOE,
  title={Impact of endurance training on murine spontaneous activity, muscle mitochondrial DNA abundance, gene transcripts, and function.},
  author={Lisa S Chow and Laura J. Greenlund and Yan W. Asmann and Kevin R Short and Shelly K McCrady and James A. Levine and K. Sreekumaran Nair},
  journal={Journal of applied physiology},
  year={2007},
  volume={102 3},
  pages={1078-89}
}
We hypothesized that enhanced skeletal muscle mitochondrial function following aerobic exercise training is related to an increase in mitochondrial transcription factors, DNA abundance [mitochondrial DNA (mtDNA)], and mitochondria-related gene transcript levels, as well as spontaneous physical activity (SPA) levels. We report the effects of daily treadmill training on 12-wk-old FVB mice for 5 days/wk over 8 wk at 80% peak O(2) consumption and studied the training effect on changes in body… CONTINUE READING