Impact of early vs. late childhood early life stress on brain morphometrics

  title={Impact of early vs. late childhood early life stress on brain morphometrics},
  author={Laurie M. Baker and Leanne M. Williams and Mayuresh S. Korgaonkar and Ronald Cohen and Jodi M. Heaps and Robert H. Paul},
  journal={Brain Imaging and Behavior},
Previous studies of early life trauma suggest that in addition to its emotional impact, exposure to early life stress (ELS) is associated with alterations in brain structure. However, little attention has been devoted to the relationship between emotional processing and brain integrity as a function of age of ELS onset. In the present study we examined whether ELS onset in older ages of youth rather than younger ages is associated with smaller limbic and basal ganglia volumes as measured by… 

The association between latent trauma and brain structure in children

The results suggest that trauma may be an important risk factor for structural aberrations, specifically for cortical thickness differences in frontal and cingulate regions in children.

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Findings suggest an association between childhood trauma exposure and adulthood cognitive function and brain structure and relationships appear to differ between individuals who do and do not develop depression.

Prefrontal cortex and amygdala anatomy in youth with persistent levels of harsh parenting practices and subclinical anxiety symptoms over time during childhood

Smaller gray matter volumes in the prefrontal cortex regions and in the amygdala were observed in youth with high versus low levels of harsh parenting over time, and significant interaction effects between parenting practices and subclinical anxiety symptoms in rostral anterior cingulate cortical thickness and in amygdala volume were observed.

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Long-Term Occupational Stress Is Associated with Regional Reductions in Brain Tissue Volumes

The present findings of morphological changes in these regions confirm the previous conclusion that symptoms from occupational stress merit careful investigations and targeted treatment and indicate a morphological involvement of the frontostriatal circuits.

Neuroimaging and Cognitive Outcomes in Adults with Human Immunodeficiency Virus and Early Life Stress

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Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei

Effects of early life stress on cognitive and affective function: an integrated review of human literature

Higher-order, complex cognitive and affective functions associated with brain regions undergoing protracted postnatal development are particularly vulnerable to the deleterious effects of ELS, and the amygdala is particularly sensitive to early ELS.

The impact of early life stress on psychophysiological, personality and behavioral measures in 740 non-clinical subjects.

The impact of a history of ELS showed significant effects on brain function, personality dimensions and nicotine dependence, and was associated with significantly decreased power across the EEG spectrum.

The effects of stress on memory and the hippocampus throughout the life cycle: Implications for childhood development and aging

Clinical studies in traumatized human populations with posttraumatic stress disorder (PTSD) have replicated studies in animals, showing reduction in volume of the hippocampus measured with magnetic resonance imaging and associated memory deficits.

Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly.

  • R. PaulOmar Haque E. Gordon
  • Psychology
    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
  • 2005

Neurobiological effects of childhood abuse: implications for the pathophysiology of depression and anxiety

Early life traumatic events, occurring during a period of neuronal plasticity, appear to permanently render neuroendocrine stress response systems supersensitive, and likely represent long-term risk factors for the development of psychopathology after exposure to additional stress.

Effects of stress throughout the lifespan on the brain, behaviour and cognition

A model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.

Developmental changes in hypothalamus–pituitary–adrenal activity over the transition to adolescence: Normative changes and associations with puberty

Findings show that puberty-associated increases in hypothalamic–pituitary–adrenal axis activity heightens the risk of psychopathology, and higher sympathetic tone was associated with more fearful temperament, whereas greater cortisol reactivity wasassociated with more anxious and depressed symptoms for girls.

Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity.

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