Impact of early life ovariectomy on blood pressure and body composition in a female mouse model of systemic lupus erythematosus.

@article{Gilbert2014ImpactOE,
  title={Impact of early life ovariectomy on blood pressure and body composition in a female mouse model of systemic lupus erythematosus.},
  author={Emily L. Gilbert and M. J. Ryan},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2014},
  volume={307 8},
  pages={R990-7}
}
Because of the preponderance of women affected by the chronic autoimmune disease systemic lupus erythematosus (SLE), estrogen is thought to contribute to SLE disease progression. This is supported by evidence from experimental animal models of SLE showing that removal of estrogen in young female mice delays autoantibody production and renal injury and… CONTINUE READING