Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis

  title={Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis},
  author={Eline J. Kraaijenvanger and Tania M. Pollok and Maximilian Monninger and Anna Kaiser and Daniel Brandeis and Tobias Banaschewski and Nathalie E. Holz},
  journal={Neuroscience \& Biobehavioral Reviews},

Early social adversity, altered brain functional connectivity, and mental health

Early life stress is associated with the default mode and fronto-limbic network connectivity among young adults

Exposure to early life stress (ELS) is associated with a variety of detrimental psychological and neurodevelopmental effects. Importantly, ELS has been associated with regional alterations and

Neural functional connectivity during rumination in individuals with adverse childhood experiences

ABSTRACT Background Childhood adversity has been associated with greater risk of developing psychopathology, altered processing of emotional stimuli, and changes in neural functioning. Although the

Adverse childhood experiences and fronto-subcortical structures in the developing brain

Assessing the relation between various recently occurred ACEs and morphology in the developing brain of children between 8 and 11 years of age may reveal whether more evidence for the impact of ACEs on brain development will emerge later in life.

Individual differences in threat and reward neural circuitry activation: Testing dimensional models of early adversity, anxiety and depression

Results lend partial support to theories of adversity‐related alterations in neural activation and highlight the importance of testing dimensional models of adversity and psychopathology in large sample sizes to further the understanding of the biological processes implicated.



Effects of early life stress on cognitive and affective function: an integrated review of human literature

Higher-order, complex cognitive and affective functions associated with brain regions undergoing protracted postnatal development are particularly vulnerable to the deleterious effects of ELS, and the amygdala is particularly sensitive to early ELS.

The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies

It is suggested that childhood maltreatment has sustained effects on brain function into adulthood, and potential mechanisms for conveying vulnerability to development of psychopathology are highlighted.

Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task

The findings support previous research showing that ELS is associated with impaired neurobehavioral performance and changes in brain activation, suggesting recruitment of additional cognitive resources during WM in ELS.

Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging

It is suggested that maltreatment leads to neurocognitive alterations that embed latent vulnerability to psychiatric disorder, establishing a compelling case for identifying those children at most risk and developing mechanistically informed models of preventative intervention.

Effect of Early Adversity and Childhood Internalizing Symptoms on Brain Structure in Young Men.

Adversity early in life was associated with higher levels of internalizing symptoms as well as with altered brain structure, and some of the structural variation often attributed to depression might be associated with early adversity in addition to the effect of depression.

Stress and the healthy adolescent brain: Evidence for the neural embedding of life events

It is found that prior exposure to severe adverse life events was associated with current anxiety and with increased amygdala reactivity to standardized emotional stimuli, and morphometric analyses suggest systemic alterations in structural brain development with an association between anxiety symptoms and global gray matter volume.

Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder

Findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors.

Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect.

This review aims to synthesize neuroimaging findings in children who experienced caregiver neglect as well as from studies in children, adolescents and adults who experienced physical, sexual and emotional abuse to provide preliminary answers to questions regarding the importance of type and timing of exposure, gender differences, reversibility and the relationship between brain changes and psychopathology.